Objective: To cease the increasing damage to the brain neurons following epileptic seizures, natural anti-oxidative systems play the main role. One of the most important detoxifying systems is composed of the trace element selenium and its dependent detoxifying enzyme, GLUTATHIONE PEROXIDASE. The object of this study was to evaluate serum selenium and red blood cell GLUTATHIONE PEROXIDASE activity in pediatric epileptics and compare it with that of healthy children. Material & Methods: Patients suffering from various types of epilepsy were studied during a 15-month period. Control group consisted of healthy children with no history of any neurologic disease. Serum selenium level and RBC GLUTATHIONE PEROXIDASE activity was evaluated and the results compared. Findings: Fifty three epileptic patients with a mean age of 5.5 years and 57 healthy children with a mean age of 5.6 years were enrolled in this study. Statistically significant differences in the mean values for serum selenium level (72.9 vs. 86.0 ng/ml, P=0.017) and also RBC GLUTATHIONE PEROXIDASE activity (440.6 vs. 801.0 nmol/min/ml, P=0.000) between the two groups were observed. On the other hand, after analyzing the study results, trying to introduce a value for GPx activity, which could be accepted as a reliable indicator for serum selenium deficiency in patients, was not successful.Conclusion: Findings of the present study strongly support the proposed crucial role for the trace element selenium and deficiency of its dependent enzyme, GLUTATHIONE PEROXIDASE, in epilepsy pathogenesis.

ObjectiveWe aimed to determine the relationship between serum GLUTATHIONEPEROXIDASE and febrile seizure.Materials & MethodsIn this case-control study, 43 children with simple febrile seizure (case group)were compared with 43 febrile children without seizure (control group) in termsof serum GLUTATHIONE PEROXIDASE level, measured by ELISA method. This studywas conducted in Qazvin Children Hospital, Qazvin University of MedicalSciences in Qazvin, Iran in 2012-2013. The results were analyzed and comparedin two groups.ResultsFrom 43 children 24 (53%) were male and 19 (47%) were female in childrenwith simple febrile seizure, and 26 (60%) were male and 17 (40%) were femalein febrile children without seizure (control group) (P=0.827). Serum GLUTATHIONEPEROXIDASE level was 166 U/ml (SD=107) in the case group and 141 U/ml(SD=90.5) in the control group of no significant difference.ConclusionThere was no significant relationship between serum GLUTATHIONE PEROXIDASE andsimple febrile seizure. Thus, it seems that GLUTATHIONE PEROXIDASE, an essentialcomponent of antioxidant system, does not play any role in the pathogenesis ofsimple febrile seizure.

Introduction: Important genes that may be expressed in women candidates for mastectomy due to breast cancer are important. The expression of these genes in these women can play an important role in the treatment of these patients. The aim of this study was to investigate the expression level of GLUTATHIONE PEROXIDASE and GLUTATHIONE reductase genes in mastectomies women. Procedure: After cell culture, the cell suspension was planted in 96-well microplates and treated for 24 hours in a CO2 incubator at 37 °C. To synthesize cDNA, extracted RNA molecules were used with the help of Fermentaz Revert Aid TM kit, produced in the United States. Results: The concentration of 500 micrograms of nanoparticles caused the death of more than 60% of MCF 7 cells (P< 0.001) while there was no significant difference in all concentrations of nanoparticles on the normal HEK293 cell line. Conclusion: The anti-tumor effects of zinc oxide nanoparticles were shown in increasing the expression of GLUTATHIONE PEROXIDASE and GLUTATHIONE reductase genes in MCF-7 breast cancer cell line of mastectomy candidates.